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Tofacitinib metabolite-1

Names

[ CAS No. ]:
1640971-51-2

[ Name ]:
Tofacitinib metabolite-1

Biological Activity

[Description]:

Tofacitinib metabolite-1 is a metabolite of Tofacitinib (HY-40354), a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Martin E Dowty, et al. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans. Drug Metab Dispos. 2014 Apr;42(4):759-73.

[2]. Matthias Gehringer, et al. Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres. ChemMedChem. 2014 Nov;9(11):2516-27.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H20N6O2

[ Molecular Weight ]:
328.37

Related Compounds