(R)-Zunsemetinib

Names

[ CAS No. ]:
1640282-44-5

[ Name ]:
(R)-Zunsemetinib

Biological Activity

[Description]:

(R)-Zunsemetinib is the inactive isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Zunsemetinib (ATI-450) – Investigational oral MK2 pathway inhibitor

[2]. Aclaris Therapeutics Announces ATI-450 (MK2 pathway Inhibitor) publication in Journal of Experimental Medicine

[3]. Wang C, et al. Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals. J Exp Med. 2018;215(5):1315-1325.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H22ClF2N5O3

[ Molecular Weight ]:
513.92

Related Compounds

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