1640282-44-5

1640282-44-5 structure

Name: (R)-Zunsemetinib
Chemical Name: (R)-Zunsemetinib
CAS Number: 1640282-44-5
Molecular Formula: C₂₅H₂₂ClF₂N₅O₃
Molecular Weight: 513.92
Catalog: Research Areas Inflammation/Immunology
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(R)-Zunsemetinib is the inactive isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1].

Name	(R)-Zunsemetinib

Description	(R)-Zunsemetinib is the inactive isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Zunsemetinib (ATI-450) – Investigational oral MK2 pathway inhibitor [2]. Aclaris Therapeutics Announces ATI-450 (MK2 pathway Inhibitor) publication in Journal of Experimental Medicine [3]. Wang C, et al. Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals. J Exp Med. 2018;215(5):1315-1325.

Molecular Formula	C₂₅H₂₂ClF₂N₅O₃
Molecular Weight	513.92