Odatroltide

Names

[ Name ]:
Odatroltide

Biological Activity

[Description]:

Odatroltide, as a nanoscale P-selectin inhibitor, is a nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[Target]

P-selectin[1]

[In Vitro]

Odatroltide (1 nM) effectively down-regulates P-selectin expression. DHDMIQK(KAP) effectively inhibits platelet aggregation via down-regulating the expression of P-selectin. Odatroltide effectively inhibits platelet aggregations induced by TH, AA, ADP and PAF, which are correlated with the downregulation of P-selectin expression and with the scavenging of the free radicals[1].

[In Vivo]

Odatroltide (0.01 nmol/kg) lyses the thrombus and inhibits thrombosis with a minimal[1].

[References]

[1]. Feng Q, et al. DHDMIQK(KAP): a novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus. J Mater Chem B. 2016;4(36):5991-6003.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₅₁N₇O₈

[ Molecular Weight ]:
661.79

Related Compounds

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