PLX7922

Names

[ Name ]:
PLX7922

Biological Activity

[Description]:

PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

RAF[1]

[In Vitro]

PLX7922 (1-1000 nM) inhibits pERK in BRAFV600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1].

[References]

[1]. Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₅FN₆O₂S₂

[ Molecular Weight ]:
464.58

Related Compounds

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