Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PLX7922
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1638772-61-8

1638772-61-8 structure

1638772-61-8 structure

Name: PLX7922
Chemical Name: PLX7922
CAS Number: 1638772-61-8
Molecular Formula: C₂₀H₂₅FN₆O₂S₂
Molecular Weight: 464.58
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2021-09-05 19:57:01
Modify Date: 2024-01-14 05:45:45
PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].

Name	PLX7922

Description	PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	RAF[1]
In Vitro	PLX7922 (1-1000 nM) inhibits pERK in BRAFV600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1].
References	[1]. Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-6.

Molecular Formula	C₂₀H₂₅FN₆O₂S₂
Molecular Weight	464.58