ML303

Names

[ Name ]:
ML303

Biological Activity

[Description]:

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[Target]

EC50: 0.7 μM (H1N1)[1].

[In Vitro]

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1]. Western Blot Analysis[1] Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours. Concentration: 20 μM. Incubation Time: 6 hours. Result: Restored IFN-β mRNA levels in MDCK cells.

[References]

[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₆F₃N₃O₂

[ Molecular Weight ]:
399.37

[ Storage condition ]:
-20°C

Related Compounds

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