hnNOS-IN-3

Names

[ Name ]:
hnNOS-IN-3

[Synonym ]:
Carbamimidothioic acid, N'-[4-(trifluoromethyl)phenyl]-, ethyl ester, hydrochloride (1:1)
TFPI HCL
EPIT HCL
MFCD01320531
Ethyl N'-[4-(trifluoromethyl)phenyl]carbamimidothioate hydrochloride (1:1)
TFPI hydrochloride
SEPIT HCL
ETPI,HYDROCHLORIDE

Biological Activity

[Description]:

hnNOS-IN-3 (compound 39) is a selective nNOS inhibitor, with a Ki of 0.32 μM. The nNOS binding of hnNOS-IN-3 is competitive with L-arginine. The selectivity of hnNOS-IN-3 for nNOS versus iNOS (Ki=37 μM) and eNOS (Ki=9.4 μM) is 115-fold and 29-fold, respectively[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Neurological Disease

[Target]

nNOS:0.32 μM (Ki)

eNOS:9.4 μM (Ki)

iNOS:37 μM (Ki)

[References]

[1]. Shearer BG, et al. Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem. 1997 Jun 6;40(12):1901-5.

Chemical & Physical Properties

[ Density]:
1.27 g/cm3

[ Boiling Point ]:
322.3ºC at 760 mmHg

[ Melting Point ]:
143-147ºC

[ Molecular Formula ]:
C₁₀H₁₂ClF₃N₂S

[ Molecular Weight ]:
284.73

[ Flash Point ]:
148.8ºC

[ Exact Mass ]:
284.036194

[ PSA ]:
61.18000

[ LogP ]:
4.77990

[ Vapour Pressure ]:
0.000281mmHg at 25°C

Safety Information

[ Safety Phrases ]:
S24/25

Related Compounds

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