Irsenontrine maleate

Names

[ Name ]:
Irsenontrine maleate

Biological Activity

[Description]:

Irsenontrine (E2027) maleate is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Neurological Disease

[Target]

PDE9[1]

[In Vivo]

Irsenontrine (0.3, 3.3 mg/kg; p.o.) maleate exhibits a significant ameliorative effect on the percentage of exploration of the novel object at 3.3 mg/kg in Scopolamine-induced rats[1]. Irsenontrine (1 mg/kg; p.o.) maleate and memantine hydrochloride (1 mg/kg; p.o.) combined treatment group exhibits a significantly higher percentage of exploration of the novel object than memantine hydrochloride (1 mg/kg) alone[1].

[References]

[1]. Miyamoto, et al. Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine. WO2018221550 A1

[2]. Hershey LA, et al. Pharmacological Management of Dementia with Lewy Bodies. Drugs Aging. 2019;36(4):309-319.

[3]. Eisai to present latest research on Alzheimer’s disease / dementia pipeline at the 14th international conference on Alzheimer’s & Parkinson’s diseases

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₆N₄O₇

[ Molecular Weight ]:
506.51

Related Compounds

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