KZR-616

KZR-616 (KZR616) is a potent, selective dual immunoproteasome subunit LMP7/LMP2 inhibitor with IC50 of 39 nM/139 nM, weakly inhibits β5, MECL-1 and no acitivty against β1 subunit; shows no inhibition at 10 uM against a broad selectivity panel of 20 serine, metallo-, cysteine and aspartyl proteases and 11 hydrolases; demonstrates efficacy in the anti-collagen antibody induced arthritis (CAIA) models. Other Indication Phase 2 Clinical

References 1. Johnson HWB, et al. J Med Chem. 2018 Oct 31. doi: 10.1021/acs.jmedchem.8b01201. View Related Products by Target Proteasome Other Indication