1629677-75-3
1629677-75-3 structure
- Name: KZR-616
- Chemical Name: KZR-616
- CAS Number: 1629677-75-3
- Molecular Formula: C30H42N4O8
- Molecular Weight: 586.686
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2020-01-11 15:32:50
- Modify Date: 2024-01-11 22:44:50
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KZR-616 (KZR616) is a potent, selective dual immunoproteasome subunit LMP7/LMP2 inhibitor with IC50 of 39 nM/139 nM, weakly inhibits β5, MECL-1 and no acitivty against β1 subunit; shows no inhibition at 10 uM against a broad selectivity panel of 20 serine, metallo-, cysteine and aspartyl proteases and 11 hydrolases; demonstrates efficacy in the anti-collagen antibody induced arthritis (CAIA) models. Other Indication Phase 2 Clinical
| Name | KZR-616 |
|---|
| Description | KZR-616 (KZR616) is a potent, selective dual immunoproteasome subunit LMP7/LMP2 inhibitor with IC50 of 39 nM/139 nM, weakly inhibits β5, MECL-1 and no acitivty against β1 subunit; shows no inhibition at 10 uM against a broad selectivity panel of 20 serine, metallo-, cysteine and aspartyl proteases and 11 hydrolases; demonstrates efficacy in the anti-collagen antibody induced arthritis (CAIA) models. Other Indication Phase 2 Clinical |
|---|---|
| References | References 1. Johnson HWB, et al. J Med Chem. 2018 Oct 31. doi: 10.1021/acs.jmedchem.8b01201. View Related Products by Target Proteasome Other Indication |
| Molecular Formula | C30H42N4O8 |
|---|---|
| Molecular Weight | 586.686 |