4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide

ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice[1].

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH)

Research Areas >> Metabolic Disease

ALDH2

ALDH2 modulator 1 (compound 161) (10 mg/kg for i.v.; 40, 60 mg/kg for p.o.) 降低经口服 5 g/kg 酒精处理的小鼠的血液酒精水平[1]。 Animal Model: 8-9 weeks, 20-22 g, Male C57BL6 mice (treated with PO 5/kg of EtOH)[1] Dosage: 40, 60 mg/kg for p.o. or 10 mg/kg for i.v. Administration: P.o. or i.v. Result: Reduced blood alcohol levels in mice treated with PO 5 g/kg of EtOH.

[1]. Wenjin Yang, et al. Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. WO2014160185A2.