SSTR5 antagonists 1

Names

[ Name ]:
SSTR5 antagonists 1

Biological Activity

[Description]:

SSTR5 antagonists 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively. (Compound 25a)[1]

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Metabolic Disease

[Target]

IC50: 9.6 nM (hSSTR5), 57 nM (mSSTR5)[1]

[References]

[1]. Hirose H, et al. Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus. Bioorg Med Chem. 2017 Aug 1;25(15):4175-4193.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₄FN₃O₅

[ Molecular Weight ]:
511.59

Related Compounds

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