Praliciguat

Names

[ Name ]:
Praliciguat

Biological Activity

[Description]:

Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

[Target]

EC50: 197 nM (sGC)[1]

[References]

[1]. Daniel P Zimmer, et al. Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₄F₈N₆O₂

[ Molecular Weight ]:
534.36

Related Compounds

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