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JNJ 54166060

Names

[ CAS No. ]:
1627900-41-7

[ Name ]:
JNJ 54166060

[Synonym ]:
[2-Chloro-3-(trifluoromethyl)phenyl][(4R)-1-(5-fluoro-2-pyridinyl)-4-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]methanone
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][(4R)-1-(5-fluoro-2-pyridinyl)-1,4,6,7-tetrahydro-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]-
MFCD30530737

Biological Activity

[Description]:

A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively; also is a potent inhibitor of CYP3A with IC50 of 2 uM, exhibits dose dependent occupancy in the rat brain with an ED50 of 2.3 mg/kg.

[References]

References 1. Swanson DM, et al. J Med Chem. 2016 Sep 22;59(18):8535-48. View Related Products by Target P2X Receptor

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
586.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H15ClF4N4O

[ Molecular Weight ]:
438.806

[ Flash Point ]:
308.7±30.1 °C

[ Exact Mass ]:
438.087067

[ LogP ]:
4.50

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.624

Related Compounds

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