RX-37
Names
[ CAS No. ]:
1627715-60-9
[ Name ]:
RX-37
Biological Activity
[Description]:
A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells).
[References]
References 1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39. View Related Products by Target Bromodomain
Chemical & Physical Properties
[ Molecular Formula ]:
C24H23N5O2
[ Molecular Weight ]:
413.481
Related Compounds
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