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6-deoxyjacareubin

Names

[ CAS No. ]:
16265-56-8

[ Name ]:
6-deoxyjacareubin

[Synonym ]:
5,10-dihydroxy-2,2-dimethylpyrano(3,2-b)xanthen-6(2H)-one
6-Dehydroxyjacareubin
6-Deoxyjacareubin
6-Desoxyjacareubin
5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one
Jacareubin,6-deoxy
2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl-

Biological Activity

[Description]:

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Neurological Disease

[In Vitro]

6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。

[In Vivo]

6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. Animal Model: Male SOD1G93A mice (eight weeks)[1] Dosage: 5 mg/kg Administration: Intraperitoneally (i.p.), every seven days for 1 month Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.

[References]

[1]. Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
523.4±50.0 °C at 760 mmHg

[ Melting Point ]:
214-215℃

[ Molecular Formula ]:
C18H14O5

[ Molecular Weight ]:
310.30

[ Flash Point ]:
195.8±23.6 °C

[ Exact Mass ]:
310.084137

[ PSA ]:
79.90000

[ LogP ]:
3.99

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.668

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds