<Suppliers Price>

H-Leu-Ser-Lys-Leu-OH trifluoroacetate salt

Names

[ CAS No. ]:
162559-45-7

[ Name ]:
H-Leu-Ser-Lys-Leu-OH trifluoroacetate salt

Biological Activity

[Description]:

H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Research Areas >> Inflammation/Immunology

[Target]

TGF-β1[1]


[In Vitro]

H-Leu-Ser-Lys-Leu-OH (LSKL) 也可以阻断 TSP-1 对 TGF-β1 的激活，并降低 KRFK 肽对 TGF-β1 的激活[1]。

[In Vivo]

H-Leu-Ser-Lys-Leu-OH (LSKL) (100 μg/0.5 mL; 腹腔注射; 每日给药，共 4 周; 并伴随着 DMN 的处理) 能够保护二甲基亚硝胺 (DMN) 处理 (10 mg/kg; 腹腔注射; 每周连续3天给药, 共 4 周) 导致的大鼠肝萎缩。H-Leu-Ser-Lys-Leu-OH 还可以预防肝损伤和纤维化的进展[1]。

[References]

[1]. Kondou H, et al. A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo. J Hepatol. 2003 Nov;39(5):742-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H41N5O6

[ Molecular Weight ]:
459.58000

[ Exact Mass ]:
459.30600

[ PSA ]:
196.87000

[ LogP ]:
1.63950

Safety Information

[ WGK Germany ]:
3

Related Compounds