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RWJ 50271

Names

[ CAS No. ]:
162112-37-0

[ Name ]:
RWJ 50271

Biological Activity

[Description]:

RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cytoskeleton >> Integrin

[Target]

IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)[1]


[References]

[1]. Sanfilippo PJ, et al. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J Med Chem. 1995 Mar 31;38(7):1057-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17F3N4O2S

[ Molecular Weight ]:
410.41

[ Exact Mass ]:
410.10200

[ PSA ]:
111.77000

[ LogP ]:
4.01000

Related Compounds