RWJ-445167

Names

[ CAS No. ]:
226566-43-4

[ Name ]:
RWJ-445167

[Synonym ]:
N-[2-(Carbamimidamidooxy)ethyl]-2-[6-methyl-3-{[(3-methylphenyl)sulfonyl]amino}-2-oxo-1(2H)-pyridinyl]acetamide
1(2H)-Pyridineacetamide, N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-6-methyl-3-[[(3-methylphenyl)sulfonyl]amino]-2-oxo-
N-[2-(carbamimidamidooxy)ethyl]-2-[6-methyl-3-{[(3-methylphenyl)sulfonyl]amino}-2-oxopyridin-1(2H)-yl]acetamide

Biological Activity

[Description]:

RWJ-445167 is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
Research Areas >> Cardiovascular Disease

[Target]

Ki: 4.0 nM (thrombin), 230 nM (factor Xa)[1]


[References]

[1]. RWJ-445167, et al. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul;68(1):29-36.


[Related Small Molecules]

AEBSF HCl | Fondaparinux Sodium | Bivalirudin trifluoroacetate salt | Betrixaban | Gabexate mesylate | Thrombin | Metolazone | Ozagrel (sodium) | Otamixaban | Inogatran | Napsagatran hydrate | NQ 301 | BMS-654457 | Desethyl KBT-3022 | OM-189

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C18H24N6O5S

[ Molecular Weight ]:
436.485

[ Exact Mass ]:
436.152893

[ LogP ]:
-0.17

[ Index of Refraction ]:
1.644

[ Storage condition ]:
2-8℃

Related Compounds