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LEI-106

Names

[ CAS No. ]:
1620582-23-1

[ Name ]:
LEI-106

[Synonym ]:
N-[(2,2-Dimethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]-N-(4-phenoxybenzyl)glycine
Glycine, N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-
LEI-106

Biological Activity

[Description]:

LEI-106 is a potent, dual sn-1-Diacylglycerol lipase α (DAGL-α)/ABHD6 inhibitor with an IC50 of 18 nM for DAGL-α and a Ki of 0.8 μM for ABHD6. LEI-106 inhibits the hydrolysis of [14C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α, with a Ki of 0.7 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
Research Areas >> Metabolic Disease

[References]

[1]. Janssen FJ, et al. Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. J Med Chem. 2014;57(15):6610-6622.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
664.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H27NO6S

[ Molecular Weight ]:
481.561

[ Flash Point ]:
355.4±34.3 °C

[ Exact Mass ]:
481.155914

[ LogP ]:
7.75

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds