ML398

Names

[ CAS No. ]:
1620203-88-4

[ Name ]:
ML398

[Synonym ]:
ML398
(2R)-4-(4-Chlorobenzyl)-2-(2-phenylethyl)morpholine
Morpholine, 4-[(4-chlorophenyl)methyl]-2-(2-phenylethyl)-, (2R)-

Biological Activity

[Description]:

ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4) receptor antagonist with IC50/Ki of 130 nM/60 nM; shows excellent selectivity (>100-fold) against the other dopamine receptor subtypes (D1,2S,2L,3,5; >20 uM); reverses cocaine-induced hyperlocomotion at 10 mg/kg in vivo.

[References]

References 1. Berry CB, et al. ACS Med Chem Lett. 2014 Jul 9;5(9):1060-4. View Related Products by Target Dopamine Receptor

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
421.3±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₂ClNO

[ Molecular Weight ]:
315.837

[ Flash Point ]:
208.6±24.6 °C

[ Exact Mass ]:
315.138977

[ LogP ]:
4.34

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.574

Related Compounds

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