Momelotinib-2,2,6,6-d4

Names

[ CAS No. ]:
1619927-64-8

[ Name ]:
Momelotinib-2,2,6,6-d4

Biological Activity

[Description]:

Momelotinib-2,2,6,6-d4 (CYT387-2,2,6,6-d4) is the deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an orally acitve and ATP-competitive JAK1/JAK2 inhibitor with IC50s of 11 nM and 18 nM, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> Autophagy >> Autophagy

[Target]

JAK1:11 nM (IC50)

JAK2:18 nM (IC50)


[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C23H18D4N6O2

[ Molecular Weight ]:
418.48

Related Compounds