UCB9608

Names

[ Name ]:
UCB9608

Biological Activity

[Description]:

UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> PI4K

Research Areas >> Inflammation/Immunology

[In Vitro]

UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM. UCB9608 is selective for PI4KIIIβ over PI3KC2 α, β, and γ lipid kinases[1]. UCB9608 inhibits human mixed lymphocyte reaction, the IC50 is 37 nM[1].

[References]

[1]. Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem. 2018 Aug 9;61(15):6705-6723.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₆N₈O₂

[ Molecular Weight ]:
410.47

[ Storage condition ]:
2-8℃