Bezuclastinib

Names

[ CAS No. ]:
1616385-51-3

[ Name ]:
Bezuclastinib

Biological Activity

[Description]:

Bezuclastinib (CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V (0.0001

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit

[Target]

c-Kit:<1 μM (IC50)

c-kit D816V:<1 μM (IC50)

[References]

[1]. Guoxian Wu, et al. Preparation of phenylpyrrolopyridinylheteroarylcarboxamide derivatives and analogs for use as c-kit protein kinases or mutant c-kit protein kinases modulators. Patent WO2014100620 A2.

[2]. WHO Drug Information, Vol. 35, No. 4, 2021. Geneva: World Health Organization; 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₇N₅O

[ Molecular Weight ]:
331.37

Related Compounds

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