Adafosbuvir

Names

[ Name ]:
Adafosbuvir

Biological Activity

[Description]:

Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Tetsuo Takehara, et al. JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study. J Gastroenterol. 2020 Jun;55(6):640-652.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₉FN₃O₁₀P

[ Molecular Weight ]:
545.45

Related Compounds

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