Taniborbactam

Names

[ Name ]:
Taniborbactam

Biological Activity

[Description]:

Taniborbactam is a potent inhibitor of β-lactamase, with IC50s of <100 nM for SHV-5, KPC-2, VIM-2, and AmpC β-lactamase, and 0.1 to 1 μM for OXA-1 β-lactamase, used in the research of bacterial infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: <100 nM (SHV-5 β-lactamase), <100 nM (KPC-2 β-lactamase), <100 nM (VIM-2 β-lactamase), <100 nM (AmpC β-lactamase), 0.1 to 1 μM (OXA-1 β-lactamase)[1]

[In Vitro]

Taniborbactam (Example 15) is a potent inhibitor of β-lactamase, with IC50s of <100 nM for SHV-5, KPC-2, VIM-2, and AmpC β-lactamase, and 0.1 to 1 μM for OXA-1 β-lactamase, used in the research of bacterial infections[1].

[References]

[1]. Christopher J. Burns, et al. Beta-lactamase inhibitors. WO2014089365A1

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₈BN₃O₅

[ Molecular Weight ]:
389.25

Related Compounds

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