9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine

Names

[ CAS No. ]:
1612192-04-7

[ Name ]:
9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine

[Synonym ]:
9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine
9H-Purin-2-amine, 9-(3-deoxy-3-fluoro-β-D-ribofuranosyl)-

Biological Activity

[Description]:

9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
662.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H12FN5O3

[ Molecular Weight ]:
269.23

[ Flash Point ]:
354.7±34.3 °C

[ Exact Mass ]:
269.092407

[ LogP ]:
-0.23

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.834

Related Compounds