isosorbide 2-mononitrate
Names
[ CAS No. ]:
16106-20-0
[ Name ]:
isosorbide 2-mononitrate
[Synonym ]:
2-Ismn
Glucitol,1,4:3,6-dianhydro-,2-nitrate,D
1,4:3,6-Dianhydrosorbitol 2-mononitrate
Isosorbide-5-nitrate
isosorbide-5-mononitrate
Isosorbide 2-nitrate
Isosorbide-2-mononitrate
1,4:3,6-Dianhydro-D-glucitol 2-nitrate
Chemical & Physical Properties
[ Density]:
1.56g/cm3
[ Boiling Point ]:
364.5ºC at 760mmHg
[ Melting Point ]:
>51.5°C
[ Molecular Formula ]:
C6H9NO6
[ Molecular Weight ]:
191.13900
[ Flash Point ]:
174.2ºC
[ Exact Mass ]:
191.04300
[ PSA ]:
93.74000
[ Vapour Pressure ]:
8.66E-07mmHg at 25°C
[ Index of Refraction ]:
1.542
[ Storage condition ]:
-20°C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LZ4385500
- CAS REGISTRY NUMBER :
- 16106-20-0
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C6-H9-N-O6
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,4947,1985
Safety Information
[ Hazard Codes ]:
F
[ RTECS ]:
LZ4385500
Articles
Arch. Int. Pharmacodyn. Ther. 312 , 104-9, (1991)
The effects of isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) on vascular smooth muscle tone and on cyclic nucleotide levels were studied in isolated dog aorta. The effects ...
Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.J. Pharmacol. Exp. Ther. 261(2) , 692-700, (1992)
Conflicting information existed regarding the relevance of pharmacokinetics in relation to the duration of action of organic nitrates. We examined this question using three geometric isomers of organi...
[Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation].Arzneimittelforschung 47(6) , 719-26, (1997)
An investigation in the bioequivalence of a new tablet formulation with 5 mg isosorbide dinitrate (CAS 87-33-2, ISDN 5 von ct) was performed in a two-way cross-over study with 18 subjects. The relativ...