4,4,4,4',4',4'-Hexafluoro-DL-valine

Names

[ Name ]:
4,4,4,4',4',4'-Hexafluoro-DL-valine

[Synonym ]:
2-(Difluoroamino)-2,3,4,4-tetrafluoro-3-methylbutanoic acid
EINECS 240-207-5
4,4,4,4′,4′,4′-Hexafluoro-DL-valine
2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric Acid
4,4,4,4',4',4'-Hexafluoro-DL-valine
MFCD00014349
DL-hexafluorovaline
2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric acid 4,4,4,5,5,5-Hexafluoro-DL-valine
hexafluorovaline
2-amino-3-trifluoromethyl-4,4,4-trifluorobutanoic acid

Biological Activity

[Description]:

4,4,4,4',4',4'-Hexafluoro-DL-valine is a valine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.575 g/cm3

[ Boiling Point ]:
165.9ºC at 760 mmHg

[ Melting Point ]:
204°C (dec.)

[ Molecular Formula ]:
C₅H₅F₆NO₂

[ Molecular Weight ]:
225.08900

[ Flash Point ]:
54.1ºC

[ Exact Mass ]:
225.02200

[ PSA ]:
63.32000

[ LogP ]:
1.83940

[ Index of Refraction ]:
1.349

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN3335

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis of fluorine-containing peptides. Analogues of angiotensin II containing hexafluorovaline.

J. Med. Chem. 24(9) , 1043-7, (1981)

Gamma, gammma, gammma, gammma', gamma', gammma'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis. Hex...

Long-acting angiotensin II inhibitors containing hexafluorovaline in position 8.

J. Med. Chem. 30(6) , 1097-100, (1987)

An improved synthesis of hexafluorovaline (Hfv) derivatives, i.e., DL-Hfv-OBzl and Boc-DL-Hfv, is described. Incorporation of hexafluorovaline into angiotensin resulted in [Sar1,Hfv8]AII and [Sar1,D-H...

Related Compounds

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