L -Kynurenine sulfate salt

Names

[ Name ]:
L -Kynurenine sulfate salt

[Synonym ]:
L-kynurenin,sulfate
L-KYNURENINESULPHATE
L-Kynurenin,Sulfat
L-Kynurenine sulfate salt crystalline
Kyn sulfate
L-Kynurenine sulfate salt

Biological Activity

[Description]:

L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

Research Areas >> Inflammation/Immunology

[Target]

Human Endogenous Metabolite

[References]

[1]. Benjamin J Moyer, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.

Chemical & Physical Properties

[ Boiling Point ]:
466.6ºC at 760 mmHg

[ Melting Point ]:
196 °C

[ Molecular Formula ]:
C₁₀H₁₄N₂O₇S

[ Molecular Weight ]:
306.29200

[ Flash Point ]:
236ºC

[ Exact Mass ]:
306.05200

[ PSA ]:
189.39000

[ LogP ]:
1.96300

[ Vapour Pressure ]:
1.66E-09mmHg at 25°C

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.

J. Inflamm. (Lond.) 8 , 25, (2011)

The kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites. Altered levels of KP-metabolites have been...

The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?

Cephalalgia 31 , 1029-1038, (2011)

In recent years the kynurenine family of compounds, metabolites of tryptophan, has become an area of intensive research because of its neuroactive properties. Two metabolites of this family have becom...

Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.

Infect. Immun. 79 , 4425-4437, (2011)

Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bact...