bio-THZ1

Names

[ Name ]:
bio-THZ1

Biological Activity

[Description]:

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK7[1].

[References]

[1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₂H₆₅ClN₁₂O₈S

[ Molecular Weight ]:
1053.67

Related Compounds

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