TX2-121-1

Names

[ Name ]:
TX2-121-1

Biological Activity

[Description]:

TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM.

[References]

References 1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12. View Related Products by Target EGFR

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₅₂N₈O₃

[ Molecular Weight ]:
716.931

Related Compounds

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