1603845-42-6
1603845-42-6 structure
- Name: TX2-121-1
- Chemical Name: TX2-121-1
- CAS Number: 1603845-42-6
- Molecular Formula: C42H52N8O3
- Molecular Weight: 716.931
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2020-01-13 22:22:09
- Modify Date: 2024-01-16 18:39:06
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TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM.
| Name | TX2-121-1 |
|---|
| Description | TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM. |
|---|---|
| References | References 1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12. View Related Products by Target EGFR |
| Molecular Formula | C42H52N8O3 |
|---|---|
| Molecular Weight | 716.931 |