5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-5-fluoro-uridine

Names

[ Name ]:
5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-5-fluoro-uridine

[Synonym ]:
[(2S,5R)-5-(5-Fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2,5-dihydro-2-furanyl]methyl acetate
2,4(1H,3H)-Pyrimidinedione, 1-[(2R,5S)-5-[(acetyloxy)methyl]-2,5-dihydro-2-furanyl]-5-fluoro-

Biological Activity

[Description]:

5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-5-fluoro-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₁H₁₁FN₂O₅

[ Molecular Weight ]:
270.21

[ Exact Mass ]:
270.065186

[ LogP ]:
-0.79

[ Index of Refraction ]:
1.566

Related Compounds

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