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GSK-843

Names

[ CAS No. ]:
1601496-05-2

[ Name ]:
GSK-843

[Synonym ]:
3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
Thieno[3,2-c]pyridin-4-amine, 3-(5-benzothiazolyl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)-

Biological Activity

[Description]:

GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase
Research Areas >> Inflammation/Immunology

[Target]

IC50: 6.5 nM (RIP3)[1]


[References]

[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
640.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H15N5S2

[ Molecular Weight ]:
377.49

[ Flash Point ]:
340.8±31.5 °C

[ Exact Mass ]:
377.076874

[ LogP ]:
4.90

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.832

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds