β-N-methylamino-L-alanine hydrochloride

Names

[ Name ]:
β-N-methylamino-L-alanine hydrochloride

[Synonym ]:
L-BMAA hydrochloride
(S)-2-Amino-3-(methylamino)propanoic acid hydrochloride
L-Alanine, 3-(methylamino)-, hydrochloride (1:1)
3-(Methylamino)-L-alanine hydrochloride (1:1)
(2S)-2-amino-3-(methylamino)propanoic acid,hydrochloride

Biological Activity

[Description]:

β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria, could cause amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Caller T, et, al. The Potential Role of BMAA in Neurodegeneration. Neurotox Res. 2018 Jan; 33(1): 222-226.

[2]. Cox PA, et, al. BMAA and Neurodegenerative Illness. Neurotox Res. 2018 Jan; 33(1): 178-183.

[3]. Okamoto S, et, al. β-N-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cells. Sci Rep. 2018 Dec 20; 8(1): 17995.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄H₁₁ClN₂O₂

[ Molecular Weight ]:
154.595

[ Exact Mass ]:
154.050903

[ PSA ]:
75.35000

[ LogP ]:
0.51090

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H332-H315-H319

[ Precautionary Statements ]:
P261-P301 + P312 + P330-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Improving derivatization efficiency of BMAA utilizing AccQ-Tag in a complex cyanobacterial matrix.

Amino Acids 36 , 43-8, (2009)

Two different assays have been developed and used in order to investigate the optimal conditions for derivatization and detection of acid beta-N-methyl-amino-L-alanine (BMAA) in a cyanobacterial sampl...

Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin.

Science 237 , 517, (1987)

The decline in the high incidence of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer-type dementia among the Chamorro population of the western Pacific islands of Guam and Rota, coupled wit...

Beta-N-methylamino-L-alanine (L-BMAA) is a potent agonist of 'metabolotropic' glutamate receptors.

Eur. J. Pharmacol. 181 , 327-328, (1990)

Related Compounds

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