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Huwentoxin XVI TFA

Names

[ CAS No. ]:
1600543-88-1

[ Name ]:
Huwentoxin XVI TFA

Biological Activity

[Description]:

Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Neurological Disease

[Target]

IC50: ~60 nM (N-type calcium channel)[1]


[References]

[1]. Meichun Deng, et al. Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena. Neuropharmacology. 2014 Apr;79:657-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C196H292N50O56S6

[ Molecular Weight ]:
4437.13

Related Compounds