NIBR 189

Names

[ Name ]:
NIBR 189

[Synonym ]:
(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
NIBR189

Biological Activity

[Description]:

NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).IC50 value: 16/11 nM(Binding/Functional IC50) [1]Target: EBI2/GPR183 antagonistNIBR189 is a potent and selective EBI2 antagonist with improved pharmacokinetic properties which will help to probe the physiological function of EBI2 in health and disease.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> EBI2/GPR183

Research Areas >> Inflammation/Immunology

[References]

[1]. Gessier F, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68.

[Related Small Molecules]

GSK682753A

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁BrN₂O₃

[ Molecular Weight ]:
429.30700

[ Exact Mass ]:
428.07400

[ PSA ]:
49.85000

[ LogP ]:
3.33130

[ Storage condition ]:
2-8℃

NIBR 189

Names

Biological Activity

Chemical & Physical Properties

Related Compounds