1599432-08-2

1599432-08-2 structure

Name: NIBR 189
Chemical Name: nibr-189
CAS Number: 1599432-08-2
Molecular Formula: C₂₁H₂₁BrN₂O₃
Molecular Weight: 429.30700
Catalog: Signaling Pathways GPCR/G Protein EBI2/GPR183
Create Date: 2016-06-15 15:35:06
Modify Date: 2024-01-07 11:42:13
NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).IC50 value: 16/11 nM(Binding/Functional IC50) [1]Target: EBI2/GPR183 antagonistNIBR189 is a potent and selective EBI2 antagonist with improved pharmacokinetic properties which will help to probe the physiological function of EBI2 in health and disease.

Name	nibr-189
Synonyms	(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one NIBR189

Description	NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).IC50 value: 16/11 nM(Binding/Functional IC50) [1]Target: EBI2/GPR183 antagonistNIBR189 is a potent and selective EBI2 antagonist with improved pharmacokinetic properties which will help to probe the physiological function of EBI2 in health and disease.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> EBI2/GPR183 Research Areas >> Inflammation/Immunology
References	[1]. Gessier F, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68.