Z-Gly-Pro-Phe-Leu-CHO

Names

[ CAS No. ]:
159659-05-9

[ Name ]:
Z-Gly-Pro-Phe-Leu-CHO

Biological Activity

[Description]:

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H38N4O6

[ Molecular Weight ]:
550.65

Related Compounds

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