159659-05-9

159659-05-9 structure

Name: Z-Gly-Pro-Phe-Leu-CHO
Chemical Name: Z-Gly-Pro-Phe-Leu-CHO
CAS Number: 159659-05-9
Molecular Formula: C₃₀H₃₈N₄O₆
Molecular Weight: 550.65
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2024-01-12 14:03:41
Modify Date: 2024-01-12 14:03:41
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].

Name	Z-Gly-Pro-Phe-Leu-CHO

Description	Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53.

Molecular Formula	C₃₀H₃₈N₄O₆
Molecular Weight	550.65