Bizine

Names

[ CAS No. ]:
1591932-50-1

[ Name ]:
Bizine

[Synonym ]:
Benzenebutanamide, N-[4-(2-hydrazinylethyl)phenyl]-, hydrochloride (1:2)
N-[4-(2-Hydrazinoethyl)phenyl]-4-phenylbutanamide dihydrochloride

Biological Activity

[Description]:

Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

Research Areas >> Neurological Disease

[Target]

Ki: 59 nM (LSD1)[1]

[References]

[1]. Prusevich P, et, al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20;9(6):1284-93.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₅Cl₂N₃O

[ Molecular Weight ]:
370.317

[ Exact Mass ]:
369.137482

Related Compounds

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