SPDP-C6-NHS ester

Names

[ CAS No. ]:
158913-22-5

[ Name ]:
SPDP-C6-NHS ester

[Synonym ]:
lc-spdp
spdph
bicl208

Biological Activity

[Description]:

SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Melting Point ]:
82-84ºC

[ Molecular Formula ]:
C₁₈H₂₃N₃O₅S₂

[ Molecular Weight ]:
425.52200

[ Exact Mass ]:
425.10800

[ PSA ]:
156.27000

[ LogP ]:
2.82460

[ Index of Refraction ]:
1.61

Related Compounds

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