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Coronarin D methyl ether

Names

[ CAS No. ]:
157528-81-9

[ Name ]:
Coronarin D methyl ether

[Synonym ]:
(3E)-5-Methoxy-3-{2-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone
2(3H)-Furanone, 3-[2-[(1S,4aS,8aS)-decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-5-methoxy-, (3E)-
(3Z)-5-Methoxy-3-{2-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone
2(3H)-Furanone, 3-[2-[(1S,4aS,8aS)-decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-5-methoxy-, (3Z)-

Biological Activity

[Description]:

Methoxycoronarin D can be isolated from Hedychium coronarium J. Koenig and is a potent inhibitor of NF-魏B with an IC50 value of 7.3 渭M. Methoxycoronarin D is also a selective inhibitor of COX-1 with an IC50 value of 0.9 渭M[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Endringer D C, et al. Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium[J]. Revista Brasileira de Farmacognosia, 2014, 24: 408-412.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
447.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H32O3

[ Molecular Weight ]:
332.48

[ Flash Point ]:
191.7±23.3 °C

[ Exact Mass ]:
332.235138

[ PSA ]:
35.53000

[ LogP ]:
5.65

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.516

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds