P163-0892

Names

[ Name ]:
P163-0892

Biological Activity

[Description]:

P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

P163-0892 (0-32 μg/mL, 48 h) shows antifungal activity with a MIC of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively[1]. P163-0892 has good aqueous solubility[1]. P163-0892 has no cytotoxicity and no obvious cardiotoxicity[1].

[References]

[1]. Li L, et al. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. J Med Chem. 2022 Aug 3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₀N₂O₃S

[ Molecular Weight ]:
356.44

Related Compounds

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