8-Hydroxyquinoline-2-Carboxylic Acid

Names

[ Name ]:
8-Hydroxyquinoline-2-Carboxylic Acid

[Synonym ]:
8-hydroxyquinoline-2-carboxylic acid
8-Hydroxy-2-quinolinecarboxylic acid
2-Quinolinecarboxylic acid, 8-hydroxy-
MFCD00168972
Quinaldic acid, 8-hydroxy-
8-Hydroxyquinaldic acid

Biological Activity

[Description]:

BAY32-5915 is a potent IKKα inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-κB activation[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Cancer

[Target]

IKK-α:60 nM (IC50)

[In Vitro]

BAY32-5915 (50-200 μM) has no significant inhibitory effect on NF-κB activity in melanoma cells[1].

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
426.7±30.0 °C at 760 mmHg

[ Melting Point ]:
213-214 °C

[ Molecular Formula ]:
C₁₀H₇NO₃

[ Molecular Weight ]:
189.167

[ Flash Point ]:
211.9±24.6 °C

[ Exact Mass ]:
189.042587

[ PSA ]:
70.42000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.730

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ9450000

CHEMICAL NAME :: Quinaldic acid, 8-hydroxy-

CAS REGISTRY NUMBER :: 1571-30-8

BEILSTEIN REFERENCE NO. :: 0146082

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H7-N-O3

MOLECULAR WEIGHT :: 189.18

WISWESSER LINE NOTATION :: T66 BNJ CVQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 108,924,1963 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UZ9450000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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