HS220

Names

[ Name ]:
HS220

Biological Activity

[Description]:

HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum; inhibits P. berghei parasite load in HuH7 cells with EC50 of 43 uM, with no significant change on HuH7 viability; induce a unique phenotype where parasite size in hepatocytes increases.

[References]

References 1. Raphemot R, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30391-X. View Related Products by Target Parasite

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇N₃O₃

[ Molecular Weight ]:
323.352

Related Compounds

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