1570374-32-1
1570374-32-1 structure
- Name: HS220
- Chemical Name: HS220
- CAS Number: 1570374-32-1
- Molecular Formula: C18H17N3O3
- Molecular Weight: 323.352
- Catalog: Signaling Pathways MAPK/ERK Pathway MAP3K
- Create Date: 2020-01-20 19:05:56
- Modify Date: 2024-01-08 11:41:16
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HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum; inhibits P. berghei parasite load in HuH7 cells with EC50 of 43 uM, with no significant change on HuH7 viability; induce a unique phenotype where parasite size in hepatocytes increases.
| Name | HS220 |
|---|
| Description | HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum; inhibits P. berghei parasite load in HuH7 cells with EC50 of 43 uM, with no significant change on HuH7 viability; induce a unique phenotype where parasite size in hepatocytes increases. |
|---|---|
| References | References 1. Raphemot R, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30391-X. View Related Products by Target Parasite |
| Molecular Formula | C18H17N3O3 |
|---|---|
| Molecular Weight | 323.352 |