DBIBB

Names

[ Name ]:
DBIBB

[Synonym ]:
2-{[4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]sulfamoyl}benzoic acid
Benzoic acid, 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-

Biological Activity

[Description]:

A potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors; displays 33-fold increased potency over GRI977143; mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis; enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice.

[References]

References 1. Patil R, et al. Chem Biol. 2015 Feb 19;22(2):206-16. 2. Knowlden SA, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9. View Related Products by Target Lysophospholipid Receptor

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
710.4±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₀N₂O₆S

[ Molecular Weight ]:
452.480

[ Flash Point ]:
383.5±35.7 °C

[ Exact Mass ]:
452.104218

[ LogP ]:
2.44

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.670

Related Compounds

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